Abstract: A long-term experiment comparing different crop residue (CR) managements was established in 1977 in Foggia (Apulia region, southern Italy). The objective of this study was to investigate the long-term effects of different types of crop residue management on main yield response parameters in a continuous cropping system of winter durum wheat. In order to correctly interpret the results, models accounting for spatial error autocorrelation were used and compared with ordinary least square models. Eight crop residue management treatments, based on burning of wheat straw and stubble or their incorporation with or without N fertilization and irrigation, were compared. The experimental design was a complete randomized block with five replicates. Results indicated that the dynamics of yield, grain protein content and hectolitric weight of winter durum wheat did not show any decline as usually expected when a monoculture is carried out for a long time. In addition, the temporal variability of productivity was more affected by meteorological factors, such as air temperature and rainfall, than CR management treatments. Higher wheat grain yields and hectolitric weights quite frequently occurred after burning of wheat straw compared with straw incorporation without nitrogen fertilization and autumn irrigation and this was attributed to temporary mineral N immobilization in the soil. The rate of 50 kg ha(-1) of N seemed to counterbalance this negative effect when good condition of soil moisture occurred in the autumn period, so yielding the same productive level of straw burning treatment. (C) 2016 Elsevier B.V. All rights reserved.