Abstract: Climate change is noticed and well established phenomenon, described as change in the statistical properties of the climate system, considered over long period of time, regardless of cause (Houghton, 1996). This change has been monitored on global (Rosenzweig et al., 1994; Harrison et al., 1995; Wolf et al., 1995; Watson et al., 1996; Downing et al., 2000; Sathaye et al., 1997; Sirotenko et al., 1997) and regional scale (Alexandrov et al., 2002; Lalic et al., 2012; Vučetić, 2011) by researchers, organizations and part of various programmes (IPCC, UNESCO Climate Change Initiative). In a same time, it was analysed change in agroclimatic indices, soil and water balance, crop development and yield, that quantify climate change impact on agricultural production. In recent regional studies and research projects (COST 734, 2008; ADAGIO, 2009), it was estimated and quantified climate change impact on yield and development in crop production of Central and Eastern European countries and Mediterranean region. The research showed a decrease in yield in several major crops, important in national food production and part of economy. A high variability in yield from year to year and decrease in yield was showed for most cereals.