Abstract: As well as the entire Mediterranean area, the Italian Apennines have been affected by increasing temperatures, rainfall extreme events and decreases in annual precipitation due to climate change. Moreover, permanent grasslands, species-diverse ecosystems characterizing the marginal areas of the Apennines landscape, are acknowledged as very sensitive and vulnerable to climate variation. Building on these premises, statistical classification models coupled with data integration by GIS techniques, were used to territorially assess future climate change impacts on pastoral communities on the Italian Apennines chain. Specifically, a machine learning approach (Random Forest – RF), firstly calibrated  for the present period and then applied to future conditions, as projected by HadCM3 General Circulation Model (GCM), was used to simulate potential expansion/reduction and/or altitudinal shifts of the Apennine pasturelands in two time slices, centred on 2050 and 2080, under A2 and B2 SRES scenarios. RF classification model proved to be robust and very efficient to predict lands suited to pastures with regards to present period (classification error: 12%). Furthermore, according to RF simulations, relevant reductions (46 and 34%) of areas potentially suitable for pastoral resource are expected under A2 at the middle and end of the century, respectively, as depicted by the GCM and SRES scenarios. Moreover, progressive upwards shifts are predicted by the model under both SRES scenarios. These reductions will likely interest the central area of the chain threatening the typical and unique herbaceous biodiversity characterizing the Apennine pasturelands.