Abstract: In this study at the regional scale, the model DSSAT CERES-Wheat was applied in order to simulate the cultivation of winter durum wheat (WW) and to estimate the green water (GW) and the blue water (BW) through a dual-step approach (with and without supplemental irrigation). The model simulation covered a period of 30 years for three scenarios including a reference period and two future scenarios based on forecasted global average temperature increase of 2 and 5 degrees C. The GW and BW contribution for evapo transpiration requirement is presented and analyzed on a distributed scale related to the Puglia region (Southern Italy) characterized by high evaporative demand of the atmosphere. The GW component was dominant compared to BW, covering almost 90% of the ETc of WW Under a Baseline scenario the weight BW was 11%, slightly increased in the future scenarios. GW appeared dependent on the spatial and temporal distribution of rainfall during the crop cycle, and to the hydraulic characteristics of soil for each calculation unit. After considering the effects of climate change on irrigation requirement of WW we carried out an example of analysis in order to verify the economic benefit of supplemental irrigation for WW cultivation. The probability that irrigation generates a negative or zero income ranged between 55 and 60% and climate change did not impact the profitability of irrigation for WW as simulated for the economic and agro-pedoclimatic conditions of Puglia region considered in this study.