Abstract: Climate change scenarios of seasonal minimum and maximum temperature over different Italian agricultural areas, during the periods 2021–2050 and 2071–2100 against 1961–1990, are assessed. The areas are those selected in the framework of the Agroscenari project and are represented by: Padano–Veneta plain, Marche, Beneventano, Destra Sele, Oristano, Puglia and Sicilia, all areas of prominent agricultural vocation with excellence productions. A statistical downscaling technique applied to ENSEMBLES global climate simulations, emission scenario A1B, is used to achieve this objective. The statistical scheme consists of a multivariate regression based on Canonical Correlation Analysis. The scheme is constructed using large-scale fields derived from ECMWF reanalysis and seasonal mean minimum, maximum temperature derived from national observed daily gridded data that cover 1959–2008 period. Once the most skillful model has been selected for each season and variable, this is then applied to GCMs of ENSEMBLES runs. The statistical downscaling method developed reveals good skill over the case studies of the present work, underlying the possibility to apply the scheme over whole Italian peninsula. In addition, the results emphasize that the temperature at 850 hPa is the best predictor for surface air temperature. The future projections show that an increase could be expected to occur under A1B scenario conditions in all seasons, both in minimum and maximum temperatures. The projected increases are about 2 °C during 2021–2050 and between 2.5 and 4.5 °C during 2071–2100, respect to 1961–1990. The spatial distribution of warming is projected to be quite uniform over the territory to the end of the century, while some spatial differences are noted over 2021–2050 period. For example, the increase in minimum temperature is projected to be slightly higher in areas from northern and central part than those situated in the southern part of Italian peninsula, during 2021–2050 period. The peak of changes is projected to appear during summer season, for both minimum and maximum temperature. The probability density function tends to shift to warmer values during both periods, with increases more intense during summer and to the end of the century, when the lower tail is projected to shift up to 3 °C and the upper tail up to 6 °C. All these projected changes have important impacts on viticulture, intensive fruit and tomatoes, some of the main agricultural systems analyzed in the Agroscenari project.