Abstract: The numerical crop growth model Italian Vineyard Integrated Numerical model for Estimating physiological values (IVINE) was developed in order to evaluate environmental forcing effects on vine growth. The IVINE model simulates vine growth processes with parameterizations, allowing the understanding of plant conditions at a vineyard scale. It requires a set of meteorology data and soil water status as boundary conditions. The primary model outputs are main phenological stages, leaf development, yield, and sugar concentration. The model requires setting some variety information depending on the cultivar: At present, IVINE is optimized for Vitis vinifera L. Nebbiolo, a variety grown mostly in the Piedmont region (northwestern Italy). In order to evaluate the model accuracy, IVINE was validated using experimental observations gathered in Piedmontese vineyards, showing performances similar or slightly better than those of other widely used crop models. The results of a sensitivity analysis performed to highlight the effects of the variations of air temperature and soil water potential input variables on IVINE outputs showed that most phenological stages anticipated with increasing temperatures, while berry sugar content saturated at about 25.5 °Bx. Long-term (60 years, in the period 1950–2009) simulations performed over a Piedmontese subregion showed statistically significant variations of most IVINE output variables, with larger time trend slopes referring to the most recent 30-year period (1980–2009), thus confirming that ongoing climate change started influencing Piedmontese vineyards in 1980.